2018
Patlatzoglou, K., Chennu, S., Boly, M., Noirhomme, Q., Bonhomme, V., Brichant, J.-F., Gosseries, O. and Laureys, S. 2018. Deep Neural Networks for Automatic Classification of Anesthetic-Induced Unconsciousness. The 11th International Conference on Brain Informatics. Arlington, Texas. PDF
Thibaut, A., Chennu, S., Chatelle, C., Martens, G., Annen, J., Cassol, H. & Laureys, S. 2018. Theta network centrality correlates with tDCS response in disorders of consciousness. Brain Stimulation, In press. PDF
Bareham, C. A., Allanson, J., Roberts, N., Hutchinson, P. J. A., Pickard, J. D., Menon, D. K. & Chennu, S. 2018. Longitudinal Bedside Assessments of Brain Networks in Disorders of Consciousness: Case Reports From the Field. Frontiers in Neurology, 9. PDF
2017
Chennu, S., Annen, J., Wannez, S., Thibaut, A., Chatelle, C., Cassol, H., Martens, G., Schnakers, C., Gosseries, O., Menon, D. & Laureys, S. 2017. Brain networks predict metabolism, diagnosis and prognosis at the bedside in disorders of consciousness. Brain, awx163. PDF
Canales-Johnson, A., Billig, A., Olivares, F., Gonzalez, A., Garcia, M. D. C., Silva, W., Ciraolo, C., Vaucheret, E., Mikulan, E., Ibanez, A., Noreika, V., Chennu, S. & Bekinschtein, T. 2017. Integration And Differentiation Of Neural Information Dissociate Between Conscious Percepts. bioRxiv. PDF
Noreika, V., Kamke, M. R., Canales-Johnson, A., Chennu, S., Mattingley, J. B. & Bekinschtein, T. A. 2017. Neurobehavioral dynamics of drowsiness. bioRxiv. PDF
2016
Chennu, S., Noreika, V., Gueorguiev, D., Shtyrov, Y., Bekinschtein, T. & Henson, R. 2016. Silent Expectations: Dynamic Causal Modelling of Cortical Prediction and Attention to Sounds that Weren't. The Journal of Neuroscience, 36(32), 8305-831. PDF
Panda, R., Bharath, R. D., Upadhyay, N., Mangalore, S., Chennu, S. & Rao, S. L. 2016. Temporal dynamics of the default mode network characterise meditation-induced alterations in consciousness. Frontiers in Human Neuroscience, 10, 1-12. PDF
Chennu, S., Stamatakis, E. A. & Menon, D. K. 2016. The see-saw brain: recovering consciousness after brain injury. The Lancet Neurology, 15, 781-782.
Chennu, S., O'Connor, S., Adapa, R., Menon, D. K. & Bekinschtein, T. A. 2015. Brain connectivity dissociates responsiveness from drug exposure during propofol-induced transitions of consciousness. PLOS Computational Biology, 12(1), e1004669. PDF.
The research in this article showed that resting EEG brain connectivity can predict and track the transition to unconsciousness during propofol sedation, and also dissociate the loss of behavioural responsiveness from the concentration of the drug in blood. The dataset accompanying this publication is free to download at the University of Cambridge repository.
Brain networks during the transition to unconsciousness during propofol sedation (drug infusion timeline shown in red). Participants with robust networks at baseline (left panel) remained resistant to the sedative, while others showed characteristically different, weaker networks during unconsciousness (middle). All participants regained similar networks when the sedative wore off (right).
2015
Gonzalez-Gadea*, M. L., Chennu*, S., Bekinschtein, T. A., Rattazzi, A., Beraudi, A., Tripicchio, P., Moyano, B., Soffita, Y., Steinberg, L., Adolfi, F., Sigman, M., Marino, J., Manes, F. & Ibanez, A. 2015. Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder. Journal of Neurophysiology, 114, 2625-36. PDF
2014
Chennu, S., Finoia, P., Kamau, E., Allanson, J., Williams, G. B., Monti, M. M., Noreika, V., Arnatkeviciute, A., Canales-Johnson, A. S., Olivares, F., Cabezas-Soto, D., Menon, D. K., Pickard, J. D., Owen, A. M. & Bekinschtein, T. A. 2014. Spectral signatures of reorganised brain networks in disorders of consciousness. PLOS Computational Biology, 10(10), e1003887. PDF
This article shows that the rich and diversely connected networks that support awareness in the healthy brain are typically – but importantly, not always – impaired in patients in a vegetative state. Some patients had well-preserved brain networks that looked similar to those of healthy adults – these patients were those who had shown signs of hidden awareness by following commands like imagining playing tennis in an MRI scanner.
Brain networks in two behaviourally similar vegetative patients (left and middle), but one of whom imagined playing tennis (middle panel), alongside a healthy adult (right panel).
2013
Chennu, S., Finoia, P., Kamau, E., Monti, M. M., Allanson, J., Pickard, J. D., Owen, A. M. & Bekinschtein, T. 2013. Dissociable Endogenous and Exogenous Attention in Disorders of Consciousness. NeuroImage: Clinical, 3, 450-461. PDF
In the research leading up to this article, we used EEG to show that a vegetative patient was able to flexibly direct selective attention to words.
Chennu, S., Alsufyani, A., Filetti, M., Owen, A. & Bowman, H. 2013. The cost of space independence in P300-BCI spellers. Journal of NeuroEngineering and Rehabilitation, 10(1), 82. PDF
Chennu, S., Noreika, V., Gueorguiev, D., Blenkmann, A., Kochen, S., Ibáñez, A., Owen, A. M. & Bekinschtein, T. A. 2013. Expectation and attention in hierarchical auditory prediction. The Journal of Neuroscience, 33(27), 11194-11205. PDF
2012
Cruse, D., Chennu, S., Fernández-Espejo, D., Payne, W., L., Young, G., Bryan & Owen, A., M. 2012. Detecting awareness in the vegetative state: Electroencephalographic evidence for attempted movements to command. PLoS ONE, 7(11), e49933. PDF
Chatelle*, C., Chennu*, S., Noirhomme, Q., Cruse, D., Owen, A. M. & Laureys, S. 2012. Brain–computer interfacing in disorders of consciousness. Brain Injury, 1-13. PDF
Chennu, S. & Bekinschtein, T. A. 2012. Arousal modulates auditory attention and awareness: insights from sleep, sedation and disorders of consciousness. Frontiers in Psychology, 3(00065). PDF
Cruse*, D., Chennu*, S., Chatelle, C., Fernández-Espejo, D., Bekinschtein, T. A., Pickard, J. D., Laureys, S. & Owen, A. M. 2012. The relationship between aetiology and covert cognition in the minimally-conscious state. Neurology, 78(11), 816-822. PDF
2011
Cruse, D., Chennu, S., Chatelle, C., Bekinschtein, T. A., Fernández-Espejo, D., Pickard, J. D., Laureys, S. & Owen, A. M. 2011. Bedside detection of awareness in the vegetative state: a cohort study. The Lancet, 378(9809), 2088-2094. PDF
The research described in this article used EEG to show that some patients in the vegetative state might possess some form of covert awareness.
* Joint first author